High cholesterol and other blood lipid disorders
Also known as: Unspecified disorders of lipoprotein metabolism or lipidaemias
General information only. Anpheros does not diagnose and does not recommend treatment. Talk to a doctor or pharmacist about your situation. In an emergency, call 112 (or your local emergency number).
In short
Lipid metabolism disorders involve lipids, which are fats or fat-like substances such as oils, fatty acids, waxes, and cholesterol. In these inherited disorders, the body may lack enough enzymes to break down lipids, or the enzymes do not work properly, preventing the conversion of fats into energy. This causes a harmful buildup of lipids that can damage cells and tissues over time, particularly in the brain, peripheral nervous system, liver, spleen, and bone marrow. While enzyme replacement therapies can help with a few of these disorders, others have no treatment, though medicines, blood transfusions, and other procedures may help manage complications.
Source: MedlinePlus, National Library of Medicine.
AI-generated summary of the sources cited on this page, checked automatically against them. Not reviewed by a clinician; not medical advice.
Codes
Description
Metabolism is the process your body uses to make energy from the food you eat. Food is made up of proteins, carbohydrates, and fats. Chemicals in your digestive system (enzymes) break the food parts down into sugars and acids, your body's fuel. Your body can use this fuel right away, or it can store the energy in your body tissues. If you have a metabolic disorder, something goes wrong with this process.
Lipid metabolism disorders, such as Gaucher disease and Tay-Sachs disease, involve lipids. Lipids are fats or fat-like substances. They include oils, fatty acids, waxes, and cholesterol. If you have one of these disorders, you may not have enough enzymes to break down lipids. Or the enzymes may not work properly and your body can't convert the fats into energy. They cause a harmful amount of lipids to build up in your body. Over time, that can damage your cells and tissues, especially in the brain, peripheral nervous system, liver, spleen, and bone marrow. Many of these disorders can be very serious, or sometimes even fatal.
These disorders are inherited. Newborn babies get screened for some of them, using blood tests. If there is a family history of one of these disorders, parents can get genetic testing to see whether they carry the gene. Other genetic tests can tell whether the fetus has the disorder or carries the gene for the disorder.
Enzyme replacement therapies can help with a few of these disorders. For others, there is no treatment. Medicines, blood transfusions, and other procedures may help with complications.
Related terms in the cited sources
Medicines with an official indication for this condition
- Sebelipase alfa Treatment
In alphabetical order.
Next to it in ICD-10
- E75Lipid storage disorders
- E76Mucopolysaccharidoses (glycosaminoglycan disorders)
- E77Glycoproteinosis, unspecified
- E84Cystic Fibrosis
- E85Amyloidosis
- E86Dehydration (volume depletion)
Neighbouring codes in the classification, not a medical link.
External resources
Questions
What is the ICD-10 code for High cholesterol and other blood lipid disorders?
E78 (WHO, International Classification of Diseases, 10th Revision).
What is the ICD-11 code for High cholesterol and other blood lipid disorders?
5C8Z: Unspecified disorders of lipoprotein metabolism or lipidaemias (WHO, ICD-11 for Mortality and Morbidity Statistics).
Sources and attribution
- ICD-11 for Mortality and Morbidity Statistics, © World Health Organization, licensed under CC BY-ND 3.0 IGO.
- Names other than the official source titles: Anpheros translations and plain-language names, made with AI assistance and checked automatically; the source names are in English.
- Source: MedlinePlus, National Library of Medicine.
- Source: European Medicines Agency (EMA) — EPAR. © European Medicines Agency.
- ICD-10 codes and titles © World Health Organization. Source: WHO, International Classification of Diseases, 10th Revision (2019).
Anpheros Search catalog 2026.10.5, published 17 October 2026. About the data →
About this page. This page brings together public information from official sources, each cited where it is used. It is not medical advice, it is not a diagnosis, and it does not tell you which treatment to take.
Treatments. Indications are quoted unchanged from official product information (European Medicines Agency, U.S. Food and Drug Administration). They describe what a medicine is approved for, not whether it is right for you. Approved uses can differ between countries. Always read the package leaflet and follow your doctor's or pharmacist's advice.
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Links between terms. "May be associated with" means the link appears in a cited source. It does not mean you have that condition.
In an emergency, call 112 (or your local emergency number). Do not delay seeking medical help because of something you read here.